h2g2 The Hitchhiker's Guide to the Galaxy: Earth Edition

OK - cheers Mikey - I stand (or rather sit) corrected - stats was never my strong point. The impression of the entry is, however, that a sibling is always a better match than a parent and it would seem from what you say that they are equally likely to be worst - you just hope you have enough of then to choose one that matches well for the antigens in question.

Might be worth saying that it is a particular small number of genes, rather than overall homology that counts.

Ugi

Phew! Changes abound:

>the grammatical bit in the new section done
>the autograft section altered accordingly
>sharing half and not at least half genes put in
>altered the cross-matching footnote to include HLA and stresses that it is a small aspect of the genetic make-up of the person
>added that the matching is more often by chance

"The impression of the entry is, however, that a sibling is always a better match than a parent and it would seem from what you say that they are equally likely to be worst - you just hope you have enough of then to choose one that matches well for the antigens in question."

Actually, parents are rarely a good enough match. In most cases, parents will share 3 of the 6 HLA genes with their child (the only way they can share more than that is if they also share HLA genes with the other parent). I seem to remember hearing that 4/6 was the absolute minimum, and that doctors generally shoot for 5 or 6/6. While (statistically) somewhat more than half of siblings will have 3 or fewer HLA genes in common with the sibling needing the donation, the remainder will have 4-6 in common (think of a normal curve with 3 as the mean and median, and a range of 0-6 matching HLA genes).


Mikey

No more nits from my part. Fine entry.

Definetly gets my recommendation.

Bye, see you on the front page.



HELL

Editorial Note: This conversation has been moved from 'Peer Review' to 'Transplantation: A Summary'.

This thread has been moved out of the Peer Review Forum because your entry has now been recommended for the Edited Guide.

You can find out what will happen to your entry here: http://www.h2g2.com/SubEditors-Process

Congratulations!

Congratulations, Witty Ditty!
Lots of
Azara

Well, I'm happy to inform you that the towe people liked your entry as much as I did, and decided to send it to the sub eds.

Thanks, It's going to be a great addition to the guide.

Do bear in mind that it takes a bit of a while till sub-editing is done, but you'll be notified when your entry is put in the guide (and festively put in the front page.


Dancer

Thank you so much! I honestly thought that this entry would sink to the bottom of PR and never be found again.

Thank you very much for recommending it and thanks to everyone who helped and commented on the entry !

Stay ,
WD (settling down with some to celebrate)

Welcome

Kampai!


Dancer