A Conversation for Drug Toxicity


Post 1

BigAl Patron Saint of Left Handers Keeper of the Glowing Pickle and Monobrows

In addition to the new uses for thalidomide, which you've listed, it's worth noting that researchers at Queen's Medical Centre, Nottingham, UK are investigating its use to treat cancer in young children.

It is thought that the stunted limbs (phocomelia) in babies born during the 1960s might have been due to amn anti=angiogenic effect of the drug (stops formation of new blood vbessels in the limbs). This very property might make it useful against cancer which, being due to fast growing cells, requires a good blood supply. Early studies apparently show promise for treating people with gliomas, a fast growing form of brain tumour.
It is thought that thalidomid3e might also reduce some of the side-effects of cancer, such as hight temperatures, night sweats and weight loss.not have some of the


Post 2

clzoomer- a bit woobly

There has also been some success in treating neurofibromatosis with Thalidomide.


Post 3


The left/right handed molecule thing is a red herring: thalidomide rapidly racemises in vivo and so it is not possible to establish if one form has a different effect to the other.


Post 4

BigAl Patron Saint of Left Handers Keeper of the Glowing Pickle and Monobrows

Yes, Ewen appears to be correct. Just putting this here so that I can find it again for future reference:


smiley - smiley


Post 5


smiley - cheers for finding that out - red herrings are a pain, but they just taste so damn good smiley - drool

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