There is a widely propagated new age meme at the moment that holds that nothing is real.
It would have us believe that as you
probe through electron shells and into our atomic nuclei you find that nothing actually exists - it's
all just crinkles in space-time.

Well that may be, but it is still nothing more than reductionist time wasting.
It's quite clear that, for our purposes, those of empirical
study, some things are real. The computer on which I'm typing now, is really here and
no amount of wishing it away is going to make any difference. I can feel it's plastic contours
under my fingers and see it's pale cream form before me. I can hear the mechanical click and rattle
of it's keys in direct response to motor neuron instructions sent to my fingers.

My senses are only as good as the virtual model of the world that my mind builds from their input,
but my senses all concur - this computer exists. Moreover, my fictive, virtual model of the computer,
my only reference, agrees with the fictive, virtual models that wash through the brains of my
colleagues. We all agree that this computer exists. It is real in any sense that is meaningful.