h2g2 The Hitchhiker's Guide to the Galaxy: Earth Edition

This is pretty easy.

Materials:
1) Get a Nintindo 64 and the F-Zero racing Game. You can use other entertainment systems and games as well, but the good thing about this one is it's fast and you can have 4 people racing at once.

2) Stong vodka or other nicely strong shot-worthy drink

3) Ideally 5 people or less.

Methods:

1) 4 people race until there is a victor. The Victor takes a shot and lets the odd man out race.

2) If somebody "dies" on purpose or drives like a idjit on purpose, he takes a shot

Results:

In these kinds of racing games, there's always somebody really good, right? In this game, as the victor becomes more victorious, his driving skills go down and down until he's pretty much driving in circles or bouncing into walls that, "Really aren't there! Hey, stop laughing at me!" Next, the 2nd best driver goes down in sobriety. The modifier of people who die either on accident or on purpose means other folks are getting nicely langered up as well. Net result: 4-5 really drunk people who need to find a waste bin in a hurry. Enjoy.

Also, you can do this with First Person Shooter games. My roommates and I had a LAN party shortly after my 21st birthday. The rule was if you kill someone, take a drink.

Thus, those who are really good get really bad really quickly. The best was when one could rack up mass kills by sitting a sniping.

Oops, that "sitting AND sniping."