A Conversation for Smallpox - A world killer

A876567 - Smallpox - A world killer

Post 21

Felonious Monk - h2g2s very own Bogeyman

The fact remains that the tone of the entry is highly speculative, rather than descriptive of anything which has happened to date. You don't seem to be addressing our concerns about it.


A876567 - Smallpox - A world killer

Post 22

Orcus

What proof of that is there? I suspect that isn't the case at all.

There is a *lot* of work that has been and is still being done on the virulence factors (the way bacteria and viruses become virulent - ie. pathological or 'nasty') and largely we don't actually have much of a clue how these things work in nature, let alone actively going about and changing an organism to a nastier form.


A876567 - Smallpox - A world killer

Post 23

Chantywrassler Two pounds a month and you too can be a CNUT

Just a few thoughts:-

Cowpox is not a weakened form of smallpox, that's like saying chimps are a weakened form of humans.

What is a "normal cell"?

If I remember right the Smallpox virus is as large, if not larger, than some bacteria.

"A virus cell" - there's no such thing. Try "virion" or "virus particle"

"The virus lands on a cell and injects the nucleus with its strand of DNA and then dies"
Smallpox replication occurs in the cytoplasm, not the nucleus.

"Smallpox usually lives in cool or dry places where it can replicate"
All viruses are intracellular parasites and require host cells in order to replicate.

You don't give our immune system any credit whatsoever in tackling infection yet it has been successfully tackling smallpox for millennia or we wouldn't be here.

Most proteins can be denatured by heat and this includes virus proteins.

The tone is certainly not too scientific, and is far too sensationalist. It's a pity you can differentiate between viruses and bacteria, otherwise there would be a certain job waiting for you as part of the BBC News staff.

Footnote: This has came out worse sounding than I intended, so call me what you like....

....except the "E" word


A876567 - Smallpox - A world killer

Post 24

Felonious Monk - h2g2s very own Bogeyman

There are certainly too many unaddressed misgivings about this article for *me* to feel happy about picking it ATM. I can't speak for others, but if I were you I'd consider taking it out of PR for now, address these concerns and then re-submit it when you think you've done that.


A876567 - Smallpox - A world killer

Post 25

Oberon2001 (Scout)

I agree with the Monk. You should send it to the Writing Workshop as there are a few areas that need revision (ie, weekend = weakened).
Oberon2001


A876567 - Smallpox - A world killer

Post 26

Alpha5

Firstly unless you want to take up the Co-oprative group publishing corporation and tell them of there error then a smallpox viron is much smaller than a cell. That infomation was from a revision book and I think if its in there and we need to know it then its most likely to be right. Secondly, a normal cell is an unspecilised one such as a skin sell which is very similar to a hair or nail cell (both of which are dead). Thirdly, thanks for the Viron info, Ill fix that ASAP.Fourthly, the immune system is good at killing of new bactira but not viruses. That is why our immune system is not good against viruses, once it sees the same one again it will understand and attack it but not the first time. However, the immune system knows how to deal with bactira very well. Firthly thanks for the Cytoplasam info. Sixthly, Although viruses protien coats can be denatured by heat, I personaly am not going to poor boiling water down my respitory tract to try and kill smallpox. The heat in the body is designed not to denature anything, so the freindly bactira can work. However this is below the tempreture of smallpoxs denaturing point. I will try and fix a few things, thank you


A876567 - Smallpox - A world killer

Post 27

Chantywrassler Two pounds a month and you too can be a CNUT

smiley - laugh


A876567 - Smallpox - A world killer

Post 28

Orcus

I've been wracking my brains as to what the 'E' word is but in any case, can we call you Wumbeevil or Nanny the Six foot chicken? smiley - bigeyes


A876567 - Smallpox - A world killer

Post 29

Orcus

Oh and Alpha5 - try saying that bacteria are generally much smaller than a Eukaryotic cell.
All cells with a nucleus are termed Eukaryotic - so this term will include all of our cell types. Skin cells by their very name *are* specialised into being -well, skin. smiley - smiley The only cells that we have that are not specialised are Stem cells - maybe you've heard of them?

And please learn some more about the immune system because you clearly don't know what you are talking about at the moment.

Orcus


A876567 - Smallpox - A world killer

Post 30

Chantywrassler Two pounds a month and you too can be a CNUT

I didn't realise you were the shy type Orcus, why not just call me Fluffybunnykins like you usually do?smiley - loveblush

Well "E" could be for Escherichia, but it's not.

"E" is for En...

"E" is for Eng........

.....don't ever call me Engelbert Humperdincksmiley - grr


A876567 - Smallpox - A world killer

Post 31

Chantywrassler Two pounds a month and you too can be a CNUT

OK Holly, looks like it's time to put away The Junior Encyclopaedia of Space

http://www.uct.ac.za/depts/mmi/jmoodie/pox2.html

http://www.nas.edu/ssb/nanopanel2staley.htm


A876567 - Smallpox - A world killer

Post 32

Z

Just one comment the immune system is good against virus! the first time you get one it takes a while to mount an immune responce but the second time you get the same virus you hardley notice it.

Have you ever had flu? that is a virus, and i expcet you got over it pretty quickly. Yet every winter many elderly people are killed by flu. They had the same virus that you had but your immune system got rid of it and there's was impaired so it killed them.

Bacteria used to kill people but that was before antibiotics were introduced, so your immune system is not good at fighting all bacterial infections.


A876567 - Smallpox - A world killer

Post 33

Z

oh and the reason that heat is useful is for steilasing things so they can't pass the virus on.


A876567 - Smallpox - A world killer

Post 34

Gnomon - time to move on

I see that this entry has not been commented on in five days. I've just read it for the first time.

I do not consider it ready to go into the Edited Guide. It presents the case for Smallpox as a biological weapon as a fact. It doesn't discuss whether any nation has actually used smallpox as a weapon, whether there is any evidence that they have it in reserves or anything about how virulent smallpox would be compared with other biological weapons. There are a few typos which were pointed out by other researchers and which have not been corrected.

So perhaps, Alpha5 would give this another read through and change it in line with people's suggestions?


A876567 - Smallpox - A world killer

Post 35

Oberon2001 (Scout)

Just in case you want to add this to the entry, as it does prove that Government percieve smallpox as a real threat.
On 2nd December 2002, the Ministry of Defence (UK Governmental Department responsible for defence of the UK) issued a press statement saying it was inoculating 700 health officials against smallpox with immediate effect and ordering enough vaccine to inoculate the country.
Silly world, isn't it?
Oberon2001


A876567 - Smallpox - A world killer

Post 36

Gordon, Ringer of Bells, Keeper of Postal Codes and Maps No One Can Re-fold Properly

Silly world? Yes. Scary world? Yes. smiley - sigh

As other Scouts have commented, the doom and gloom aspect of the article is still there. As it reads, I can't pick the entry for inclusion in the Edited Guide.

I find the section on Safety Measures a little alarmist. When am I supposed to limit my travel? Now?

Same question for the gas mask. Would a gas mask be the appropriate sort of respiratory protection or would something like the masks you use when sanding or painting things be better?

Would cleaning bedclothes really be a good method of protection if you're the only person in the bed?


A876567 - Smallpox - A world killer

Post 37

Felonious Monk - h2g2s very own Bogeyman

I propose a move back to the thread, as the author seems to have Elvissed.

Any seconders?

FM


A876567 - Smallpox - A world killer

Post 38

Gordon, Ringer of Bells, Keeper of Postal Codes and Maps No One Can Re-fold Properly

Doesn't look like they've been around since the 10th of November. Seconded. smiley - erm


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