A Conversation for The Campaign to Promote Respect for Microbes: An Awareness Program

Microbes deserve recognition!

Post 141

Farlander



smiley - towel?


Microbes deserve recognition!

Post 142

SEF

Was that Terry or a terry towel? smiley - erm


Microbes deserve recognition!

Post 143

Farlander

both! smiley - laugh


Microbes deserve recognition!

Post 144

Mooing Platypus (formerly known as Gaia)

man! There hasn't been anthing going on for a LONG time!!!!

and I have nothing to start the conversation back up...........smiley - erm


Microbes deserve recognition!

Post 145

Santragenius V

Hmmm - what about the recent story of the archae bacteria, Strain 121?

Living at 121°C?? Well, some like it hot! smiley - winkeye

(http://news.bbc.co.uk/2/hi/science/nature/3144397.stm)


Microbes deserve recognition!

Post 146

Farlander

well, at least they're generally nice guys (hey, they're our most precious source of molecular work enzymes!!!). did you know that high temperatures and most sterilizing chemicals like glutaraldehyde *can't* destroy prions? smiley - yikes



Microbes deserve recognition!

Post 147

Santragenius V

Yeah - they're tough little proteins.

Apparently there's a sterilization protocol out there (used in some labs which tests for BSE) which specifies autoclaving at 136°C for 5 hours... I haven't dug into it enough to have a clue as to whether it's sufficient..


Microbes deserve recognition!

Post 148

Farlander

yeah, i read something similar somewhere else.

the scary part is that back when i was doing heat-shock protein work (salmonella typhi hsps), i once got hold of this excellent reference book on chaperonins. i was using that to solve the identity mystery regarding a couple of proteins when i found *prions* listed in the same table. under the heading 'housekeeping molecules'. it was at about the same time that i found a paper in one (then) recent molecular bio journals about prions being rogue housekeeping proteins, and how a certain mutation turned them bad... deedeedeedeedeedeedeedee....

let's see if i can dig up the paper... i'm pretty sure i still have it... you interested?


Microbes deserve recognition!

Post 149

SEF

The best thing to do might be to work out a specific enzyme for snipping prions. Then engineer that into a benign bacteria and breed it.


Microbes deserve recognition!

Post 150

Farlander

that might work... except that you'd probably be snipping the good ones as well!!! unless you were to design an enzyme that specifically identifies and snips at the mutation site... but if it were a *minor* mutation, then you might still accidentally get other things as well.

smiley - erm

those damned rogue prions! they've thought of everything! they're in league with the frogs!


Microbes deserve recognition!

Post 151

SEF

Are these the jurassic park frogs or some other ones?


Microbes deserve recognition!

Post 152

Farlander

all of them! all of them, i tell you! i thought that my *epiphany* was a sign of mental disease until i discovered that tom holt had been enlightened as well.

my dogs are apparently aware of the frogs' ploy to take over the world as well. i caught sebastian interrogating one once...honest!


smiley - winkeye


Microbes deserve recognition!

Post 153

SEF

I like frogs. smiley - erm


Microbes deserve recognition!

Post 154

Farlander

oh dear.... they've gotten to you too, i see. -sigh-

smiley - erm

ribbit ribbit


Microbes deserve recognition!

Post 155

SEF

This may not work very well:

smiley - space©©
(\\//)
=~ ~=


Microbes deserve recognition!

Post 156

Farlander

smiley - laugh

ribbit. i saw that. pretty good, actually.


Microbes deserve recognition!

Post 157

SEF

Microbes are a bit harder.

©©©©©© ©©
smiley - spacesmiley - spacesmiley - space©©©©


Microbes deserve recognition!

Post 158

Farlander

hey, you forgot

~ ~ ~ ~ (spirochetes)
, , , , (vibrios)

and oooooo oo ooo

smiley - winkeye


Microbes deserve recognition!

Post 159

Terry Teadreg

Saccharomyces (my favourites):
0Oo OoOooO

(they don't really look like this, do they?)

smiley - cheers Terry


Microbes deserve recognition!

Post 160

Farlander

well, when they're budding they look like 8 or oO such cute critters, sacrificing their lives so that we may have bread and alcohol...

i propose a toast to 'em

smiley - cheers


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